Be Part of Research - Trial Details

Recruiting

Open to: All Genders

Age: 18 Years - 79 Years

Medical Conditions

Pulmonary heart disease and diseases of pulmonary circulation
Systemic connective tissue disorders
Other respiratory diseases principally affecting the interstitium

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Pulmonary fibrosis and pulmonary hypertension are both life threatening conditions which can be seen in isolation,or in association with other disease processes such as systemic sclerosis. In addition,both pulmonary fibrosis and pulmonary hypertension may be seen in the same patient and then the prognosis is particularly poor. In both conditions there is a reduction in the amount of oxygen transferring from the air breathed in and into the blood. They are serious and progressive lung diseases. Damage is caused to the lungs by scarring to the lung lining (pulmonary fibrosis),or where changes to the blood vessels impact the way blood is brought into the lungs (pulmonary hypertension). The changes to blood vessels results in an reduced ability to accept oxygen from the lungs. In areas where the lung is extensively damaged the oxygen levels are lower (hypoxia) than in more normal areas. There are also areas where there is extensive inflammation i.e. the presence of white blood cells that have travelled into the lung. This is thought to cause further lung damage. Our research has revealed that oxygen levels are an important determinant of white blood cell numbers in low oxygen areas. Patients with fibrosis and emphysema seem to progress to pulmonary arterial hypertension quickly and have a poor prognosis,although the reasons for this are unclear.
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Exclusion criteria for IPF/ CPFE patients: • Individuals on immunosuppressive treatment (corticosteroids,immunosuppressants) for any reason. • Individuals known to have immunosuppression,diabetes mellitus,chronic kidney disease or hepatic failure. • Individuals with a history of anaemia.Current participation in a clinical trial of treatment for IPF.. • Presence of other scarring lung problems (eg TB or cystic fibrosis). • Radiographic evidence of asbestos (e.g. pleural plaques) or other fibrogenic agents (e.g. silica dust) exposure. • Ingestion of drugs known to potentially cause interstitial lung disease (e.g. methotrexate). • Clinical or serological evidence of hypersensitivity pneumonitis (e.g. extrinsic allergic alveolitis). • Clinical or serological evidence of connective tissue disorders (e.g. rheumatoid arthritis). • Congestive cardiac failure. • Patients with a known diagnosis of malignancy. Previous thoracic radiotherapy or systemic chemotherapy for cancer. • Patients who have undergone thoracic surgery including lung volume reduction surgery or have conditions that prevent them from performing spirometry and other physiological testing. • Patients who cannot have MR imaging (e.g. due to ferro-magnetic metallic implants,or non-MRI compatible pacemakers) as per the MRI questionnaire. • Patients with renal conditions that may be aggravated by Gadolinium-based MRI contrast (eGFR < 30 ml/min) • Patients who suffer from claustrophobia. • Unable to provide informed consent or unwilling/unable to follow the procedures outlined in the protocol. Exclusion criteria for patients with suspected or known PH,SSc,or CTD: • Inability to communicate in English or convey willingness to participate. • Radiographic evidence of asbestos (e.g. pleural plaques) or other fibrogenic agents (e.g. silica dust) exposure. • Patients with a known diagnosis of malignancy. Previous thoracic radiotherapy or systemic chemotherapy for cancer. • Patients who have undergone thoracic surgery including lung volume reduction surgery or have conditions that prevent them from performing spirometry and other physiological testing. • Patients who cannot have MR imaging (e.g. due to ferro-magnetic metallic implants,or non-MRI compatible pacemakers) as per the MRI questionnaire. • Patients with renal conditions that may be aggravated by Gadolinium-based MRI contrast (eGFR < 30 ml/min) • Patients who suffer from claustrophobia. • Unable to provide informed consent or unwilling/unable to follow the procedures outlined in the protocol. Exclusion criteria for healthy volunteers • Patients who cannot have MR imaging (e.g. due to ferro-magnetic metallic implants,or non-MRI compatible pacemakers) as per the MRI questionnaire. • Patients with renal conditions that may be aggravated by Gadolinium-based MRI contrast (eGFR < 30 ml/min) • Suffer from claustrophobia • Unable to provide informed consent or unwilling/unable to follow the procedures outlined in the protocol.

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for Trial ID: CPMS 59572

Last updated 24 June 2025

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IPF-MRI

Recruiting

Open to: All Genders

Age: 18 Years - 79 Years

Medical Conditions

Observational and Interventional

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IPF-MRI

Recruiting

Open to: All Genders

Age: 18 Years - 79 Years

Medical Conditions

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Observational and Interventional

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This page is to help you find out about a research study and if you may be able to take part